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  • Is ibuprofen bad for the kidneys?

    From Mike Dippel@999:1/1 to All on Sun Mar 8 21:16:00 2026
    Ibuprofen is one of those drugs that resides in medicine cabinets all over the globe, its
    familiarity having become its greatest weakness.
    It is used like a glass of water, frequently, casually, and without much thought to the
    actual effects it is having, beyond the obvious relief it is providing from the current
    distress.
    The familiarity with the drug is certainly warranted, but from a renal standpoint, the
    actual effects it is having are worthy of a much more honest discussion than the
    packaging would suggest.


    The actual method by which the drug works is important, however, because it explains
    everything.
    Ibuprofen, an NSAID, works by inhibiting prostaglandins, which are chemical messengers that, among other duties, are responsible for controlling blood flow to the
    kidneys.

    Normally, in a well-hydrated, healthy individual, the kidneys do not depend too greatly
    on prostaglandins to ensure an adequate blood supply to the kidneys themselves.

    However, in states of physiological stress, dehydration, decreased cardiac output,
    existing kidney disease, and old age, prostaglandins are extremely important to ensure
    an adequate blood supply to the kidneys, and the inhibition of such can result in a
    significant reduction in the blood supply to the kidneys, a phenomenon known as acute
    kidney injury, which can occur in a matter of hours from the time the drug was ingested.

    More info...
    https://www.quora.com/Is-ibuprofen-bad-for-the-kidneys

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  • From Daryl Stout@999:1/14 to Mike Dippel on Thu Mar 12 23:16:13 2026
    Mike,

    Ibuprofen is one of those drugs that resides in medicine
    cabinets all over the globe, its familiarity having become its
    greatest weakness. It is used like a glass of water,
    frequently, casually, and without much thought to the actual
    effects it is having, beyond the obvious relief it is providing
    from the current distress.

    The only pain killer I have here is acetomenaphin 500 milligram
    tablets. Even taking one of these will knock me out.

    Daryl

    ... Fotoflagellation - The act of waving a Polaroid so it develops faster.
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